"Mitochondrial" photochemical drugs do not release toxic amounts of 1O(2) within the mitochondrial matrix space.

Abstract

Previously, we demonstrated that mitochondrial NAD(P)H is the primary target of singlet oxygen (1O(2)) generated by photoactivation of mitochondria-selective rhodamine derivatives. Hence, local NAD(P)H oxidation/fluorescence decrease may be used to reveal the site of intracellular 1O(2) generation. Therefore, in addition to the previously used… (More)

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