"Liquid biopsy"-ctDNA detection with great potential and challenges.

@article{Ma2015LiquidBD,
  title={"Liquid biopsy"-ctDNA detection with great potential and challenges.},
  author={Mingwei Ma and Hongcheng Zhu and Chi Zhang and Xinchen Sun and Xianshu Gao and Gang Chen},
  journal={Annals of translational medicine},
  year={2015},
  volume={3 16},
  pages={
          235
        }
}
Circulating tumor DNA (ctDNA) is now being extensively studied as it is a noninvasive "real-time" biomarker that can provide diagnostic and prognostic information before, during treatment and at progression. These include DNA mutations, epigenetic alterations and other forms of tumor-specific abnormalities such as microsatellite instability (MSI) and loss of heterozygosity (LOH). ctDNA is of great value in the process of cancer treatment. However, up to date, there is no strict standard… CONTINUE READING

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