"Intrinsic" Immunological Tolerance in Allophenic Mice

@article{Mintz1967IntrinsicIT,
  title={"Intrinsic" Immunological Tolerance in Allophenic Mice},
  author={B. Mintz and W. Silvers},
  journal={Science},
  year={1967},
  volume={158},
  pages={1484 - 1487}
}
Mice experimentally derived from pairs of conjoined, undifferentiated, cleavage-stage embryos of different histocompatibility genotypes can retain cells of each strain, which still produce their characteristic antigenic products. The animals are permanently tolerant of cells of both original types, remain free of runt disease, and display a normal and specific immune response to introduction of a foreign antigen. Absence of autoimmunity in development of ordinary animals is explainable by the… Expand
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The experiments to be described in this article provide a solution—at present only a ‘laboratory’ solution—of the problem of how to make tissue homografts immunologically acceptable to hosts whichExpand
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  • B. Mintz
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1967
TLDR
This work has shown that melanocytes are clonally derived from a fixed number of primordial melanoblasts, and when these diverse cells coexist, they follow a given arrangement so that they reproduce a color pattern. Expand
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