"Intact nephrons" as the primary origin of proteinuria in chronic renal disease. Study in the rat model of subtotal nephrectomy.

@article{Yoshioka1988IntactNA,
  title={"Intact nephrons" as the primary origin of proteinuria in chronic renal disease. Study in the rat model of subtotal nephrectomy.},
  author={Tadao Yoshioka and Hiroshi Shiraga and Yuichi Yoshida and Agnes Fogo and Alan D. Glick and William M. Deen and John R. Hoyer and Iekuni Ichikawa},
  journal={The Journal of clinical investigation},
  year={1988},
  volume={82 5},
  pages={1614-23}
}
Single nephron filtration rate of albumin (SNGFRAlb) was measured in remnant nephrons of Munich-Wistar rats 4-6 wk after subtotal nephrectomy (NPX). Serial thin-section histological analysis was then conducted on the same glomeruli by light microscopy. SNGFRAlb ranged from 1 to 15 times normal. However, a direct relationship between abnormalities of structure and function was not seen, e.g. the glomeruli with the fewest structural abnormalities and marked hyperfiltration often had the highest… CONTINUE READING

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