"IF-pathies": a broad spectrum of intermediate filament-associated diseases.

@article{Omary2009IFpathiesAB,
  title={"IF-pathies": a broad spectrum of intermediate filament-associated diseases.},
  author={M. Omary},
  journal={The Journal of clinical investigation},
  year={2009},
  volume={119 7},
  pages={
          1756-62
        }
}
  • M. Omary
  • Published 2009
  • Medicine, Biology
  • The Journal of clinical investigation
  • Intermediate filaments (IFs) are encoded by the largest gene family among the three major cytoskeletal protein groups. Unique IF compliments are expressed in selective cell types, and this expression is reflected in their involvement, upon mutation, as a cause of or predisposition to more than 80 human tissue-specific diseases. This Review Series covers diseases and functional and structural aspects pertaining to IFs and highlights the molecular and functional consequences of IF-associated… CONTINUE READING
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    References

    SHOWING 1-10 OF 73 REFERENCES
    Introducing intermediate filaments: from discovery to disease.
    • 343
    • PDF
    Intermediate filaments: from cell architecture to nanomechanics
    • 574
    • PDF
    Intermediate filament proteins and their associated diseases.
    • 424
    "Heads and tails" of intermediate filament phosphorylation: multiple sites and functional insights.
    • 262
    • PDF
    Cellular integrity plus: organelle-related and protein-targeting functions of intermediate filaments.
    • 255
    Intermediate filaments: primary determinants of cell architecture and plasticity.
    • 272
    • PDF
    A structural scaffolding of intermediate filaments in health and disease.
    • 971
    The Human Intermediate Filament Database: comprehensive information on a gene family involved in many human diseases
    • 295
    Functions of the intermediate filament cytoskeleton in the eye lens.
    • 114
    • PDF