"Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice.

@article{Uhl2008HigherOA,
  title={"Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice.},
  author={George R. Uhl and Tom{\'a}s Drgon and Catherine E. Johnson and Oluwatosin O Fatusin and Qing-Rong Liu and Carlo Contoreggi and Chuan-Yun Li and Kari Buck and John Waldron Crabbe},
  journal={Biochemical pharmacology},
  year={2008},
  volume={75 1},
  pages={
          98-111
        }
}
  • George R. Uhl, Tomás Drgon, +6 authors John Waldron Crabbe
  • Published in Biochemical pharmacology 2008
  • Biology, Medicine
  • Family, adoption and twin data each support substantial heritability for addictions. Most of this heritable influence is not substance-specific. The overlapping genetic vulnerability for developing dependence on a variety of addictive substances suggests large roles for "higher order" pharamacogenomics in addiction molecular genetics. We and others have now completed genome-wide association (GWA) studies of DNAs from individuals with dependence on a variety of addictive substances versus… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 67 CITATIONS, ESTIMATED 62% COVERAGE

    Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence

    VIEW 12 EXCERPTS
    CITES RESULTS & BACKGROUND
    HIGHLY INFLUENCED

    Neural markers of genetic vulnerability to drug addiction.

    VIEW 4 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Convergent genome wide association results for bipolar disorder and substance dependence.

    VIEW 10 EXCERPTS
    CITES BACKGROUND & RESULTS

    SNPs as Co-morbid Factors for Drug Abuse and Ischemic Heart Disease

    VIEW 4 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Myelin Gene Expression: Implications for Alcohol Abuse and Dependence

    VIEW 4 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Genome-wide association for methamphetamine dependence: convergent results from 2 samples.

    VIEW 8 EXCERPTS
    CITES BACKGROUND & METHODS

    Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies

    VIEW 6 EXCERPTS
    CITES RESULTS & BACKGROUND
    HIGHLY INFLUENCED

    FILTER CITATIONS BY YEAR

    2007
    2019

    CITATION STATISTICS

    • 6 Highly Influenced Citations