"Heterosynaptic" LTD in the dentate gyrus of anesthetized rat requires homosynaptic activity.

@article{Abraham2007HeterosynapticLI,
  title={"Heterosynaptic" LTD in the dentate gyrus of anesthetized rat requires homosynaptic activity.},
  author={Wickliffe C. Abraham and Barbara B Logan and Amy R Wolff and Lubica Benuskov{\'a}},
  journal={Journal of neurophysiology},
  year={2007},
  volume={98 2},
  pages={1048-51}
}
Heterosynaptic long-term depression (LTD) is conventionally defined as occurring at synapses that are inactive during a time when neighboring synapses are activated by high-frequency stimulation. A new model that combines computational properties of both the Bienenstock, Cooper and Munro model and spike timing-dependent plasticity, however, suggests that such LTD actually may require presynaptic activity in the depressed pathway. We tested experimentally whether presynaptic activity is in fact… CONTINUE READING

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