"Heads and tails" of intermediate filament phosphorylation: multiple sites and functional insights.

@article{Omary2006HeadsAT,
  title={"Heads and tails" of intermediate filament phosphorylation: multiple sites and functional insights.},
  author={M. Bishr Omary and Nam-On Ku and G Z Tao and D M Toivola and Jian Liao},
  journal={Trends in biochemical sciences},
  year={2006},
  volume={31 7},
  pages={383-94}
}
Intermediate filaments (IFs) are major components of the mammalian cytoskeleton. They are among the most abundant cellular phosphoproteins; their phosphorylation typically involves multiple sites at repeat or unique motifs, preferentially within the "head" or "tail" domains. Phosphorylation and dephosphorylation are essential for the regulation of IF dynamics by modulating the intrinsic properties of IFs: solubility, conformation and filament organization, and, in addition, for the regulation… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS