"Go with the flow": how Krüppel-like factor 2 regulates the vasoprotective effects of shear stress.

@article{Nayak2011GoWT,
  title={"Go with the flow": how Kr{\"u}ppel-like factor 2 regulates the vasoprotective effects of shear stress.},
  author={Lalitha V. Nayak and Zhiyong Lin and Mukesh K Jain},
  journal={Antioxidants & redox signaling},
  year={2011},
  volume={15 5},
  pages={1449-61}
}
Laminar shear stress is known to confer potent anti-inflammatory, antithrombotic, and antiadhesive effects by differentially regulating endothelial gene expression. The identification of Krüppel-like factor 2 as a flow-responsive molecule has greatly advanced our understanding of molecular mechanisms governing vascular homeostasis. This review summarizes the current understanding of Krüppel-like factor 2 action in endothelial gene expression and function.