"Dedifferentiated" chordoma. A clinicopathologic and immunohistochemical study of three cases.

@article{Meis1987DedifferentiatedCA,
  title={"Dedifferentiated" chordoma. A clinicopathologic and immunohistochemical study of three cases.},
  author={Jeanne M. Meis and Austin K. Raymond and Harry L Evans and Rodolphe Charles and Alvaro A. Giraldo},
  journal={The American journal of surgical pathology},
  year={1987},
  volume={11 7},
  pages={516-25}
}
Three cases of "dedifferentiated" chordoma arising in the sacrococcygeal region are presented. In all three cases, the "dedifferentiated" component arose de novo in conjunction with conventional chordoma. Two of these patients, whose tumors had a prominent malignant fibrous histiocytoma (MFH) component, died within 6 months of diagnosis. Both patients had lung metastases, one of which was histologically documented to be MFH. The third patient, whose initial tumor contained osteosarcoma, died 76… CONTINUE READING