"Contact inhibition" of cell division in 3T3 cells.

  title={"Contact inhibition" of cell division in 3T3 cells.},
  author={Robert W. Holley and J A Kiernan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={60 1},
The 3T3 cell, an established line of mouse fibroblast cell, has been considered to be extremely sensitive to "contact inhibition" of cell division. Under the usual culture conditions, 3T3 cells grow rapidly in sparse culture, but cell division stops after the cells become confluent, at approximately 106 cells per 6-cm dish. The cell monolayer has a typical "cobblestone" appearance. Todaro, Lazar, and Green1 have described studies of the effect of serum on cell division in these "contact… CONTINUE READING