"Cognitive Impairment Associated with Toxigenic Fungal Exposure": A Critique and Critical Analysis

  title={"Cognitive Impairment Associated with Toxigenic Fungal Exposure": A Critique and Critical Analysis},
  author={Robert J Mccaffrey and Christine L. Yantz},
  journal={Applied Neuropsychology},
  pages={134 - 137}
Recently Gordon et al. (2004) reported the results of a study relating exposure to toxigenic fungi to cognitive impairment. A number of methodological problems limit the utility of this study, including the authors' not examining a number of potential confounding variables, use of a mild traumatic brain injury group as a comparison, and problematic statistical analyses increasing the Type 1 error rate. Based on these limitations, the authors' conclusion that mold-exposed people have more… 
Cognitive Impairment Associated with Toxigenic Fungal Exposure: A Response to Two Critiques
This article documents that both sets of negative comments are based on frequent inaccuracies, mischaracterizations of the findings, and red herrings and fails to refute the implications of the study's main findings.
Has the Rolling Uterus Finally Gathered Moss? Somatization and Malingering of Cognitive Deficit in Six Cases of “Toxic Mold” Exposure
Until the literature has established a credible link between mold and neuropsychiatric/neuropsychological impairment, jurists and clinicians must consider the ethics and potential harm of exposing somatoform patients to multiple unwarranted medical evaluations.
Mold inhalation causes innate immune activation, neural, cognitive and emotional dysfunction
Innate-immune activation may explain how both toxic mold and nontoxic mold skeletal elements caused cognitive and emotional dysfunction.
Aspergillus versicolor Inhalation Triggers Neuroimmune, Glial, and Neuropeptide Transcriptional Changes
Findings indicate that the brain can detect and respond to A. versicolor inhalation exposure with changes in neuroimmune and neurotransmission gene expression, providing much needed insight into how inhaled fungal exposures can affect CNS responses and regulate neuroimmune homeostasis.
Brain “fog,” inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin
Brain “fog” is a constellation of symptoms that include reduced cognition, inability to concentrate and multitask, as well as loss of short and long term memory. Brain “fog” characterizes patients
Medical diagnostics for indoor mold exposure.
In April 2016, the German Society of Hygiene, Environmental Medicine and Preventative Medicine has provided an AWMF guideline 'Medical diagnostics for indoor mold exposure', which shall help physicians to advise and treat patients exposed indoors to mold.


Cognitive Impairment Associated With Toxigenic Fungal Exposure: A Replication and Extension of Previous Findings
Number of cognitive impairments was found to be related to depression, although few neuropsychological test scores were correlated with depression, and exposure to mycotoxins to cognitive dysfunction was found.
Indoor Mold Exposure Associated with Neurobehavioral and Pulmonary Impairment: A Preliminary Report
  • K. Kilburn
  • Medicine
    Archives of environmental health
  • 2003
Indoor mold exposures were associated with neurobehavioral and pulmonary impairments that likely resulted from the presence of mycotoxins, such as trichothecenes.
Toxic Mold and Mycotoxins in Neurotoxicity Cases: Stachybotrys, Fusarium, Trichoderma, Aspergillus, Penicillium, Cladosporium, Alternaria, Trichothecenes
It is argued that psychologists and neuropsychologists have no scientific basis for rendering opinions about causation given the current state of the literature, and speculative opinions are rendered in lieu of scientifically well-founded conclusions.
Cognitive factors in Postconcussion Syndrome symptom report.
  • J. Gunstad, J. Suhr
  • Psychology, Medicine
    Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
  • 2004
Findings are consistent with the growing number of studies that suggest non-neurologic factors may be more closely related to PCS symptom report than head injury status and raise further concern regarding use of self-reported PCS symptoms in the diagnosis of head injury.
Effects of mild traumatic brain injury cannot be differentiated from substance abuse
Patients with uncomplicated MTBIs could not be reliably differentiated from patients with substance abuse problems on these measures of concentration, memory and processing speed.
Examination of "Postconcussion-Like" Symptoms in a Healthy Sample
This study illustrates that the presence of postconcussion-like symptoms are not unique to mild head injury and are commonly found in healthy individuals, and are highly correlated with depressive symptoms.
Note on the use of the Postconcussion Syndrome Checklist.
The PCSC was significantly correlated with the Beck Depression Inventory, suggesting that general level of psychological distress is a key factor in evaluating symptoms of PCS.
Base rates of post-concussional symptoms.
In most cases, no significant difference was found between the symptoms reported by the head injured group and the uninjured group, demonstrating the importance of establishing base rates of symptoms in non-clinical populations prior to drawing conclusions about symptoms in clinical populations.
Mild Head Injury: Facts and Artifacts
The results indicated early impairments that decreased with time and the stringency of the definition of ‘mild’ TBI, and the contribution of demographics was usually significant and often stronger than the mild TBI effect.
A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary
This volume is a compilation of the neuropsychological tests currently used by the authors and their colleagues at the University of Victoria (Melbourne, Australia) Neuropsychology Laboratory. As