"Clamping" actin in polymerized form in electro-permeabilized neutrophils inhibits oxidase activation.

@article{AlMohanna1990ClampingAI,
  title={"Clamping" actin in polymerized form in electro-permeabilized neutrophils inhibits oxidase activation.},
  author={Futwan A. Al-Mohanna and Maurice B. Hallett},
  journal={Biochemical and biophysical research communications},
  year={1990},
  volume={169 3},
  pages={1222-8}
}
Electro-permeabilized neutrophils take-up small membrane-impermeant molecules into their cytoplasm, yet retain the ability to activate their oxidase and to transiently polymerize actin in response to f-met-leu-phe (fmlp). Using this system phalloidin was introduced into the cytosol in order to determine whether polymerization of actin affects oxidase activation. Cytosolic phalloidin prevented the depolymerization of actin following stimulation with fmlp, which was consequently "clamped" in the… CONTINUE READING

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