"Cat's Cradling" the 3D Genome by the Act of LncRNA Transcription.

@article{Mele2016CatsCT,
  title={"Cat's Cradling" the 3D Genome by the Act of LncRNA Transcription.},
  author={Marta Mele and John L Rinn},
  journal={Molecular cell},
  year={2016},
  volume={62 5},
  pages={
          657-64
        }
}
There is growing evidence that transcription and nuclear organization are tightly linked. Yet, whether transcription of thousands of long noncoding RNAs (lncRNAs) could play a role in this packaging process remains elusive. Although some lncRNAs have been found to have clear roles in nuclear architecture (e.g., FIRRE, NEAT1, XIST, and others), the vast majority remain poorly understood. In this Perspective, we highlight how the act of transcription can affect nuclear architecture. We synthesize… CONTINUE READING
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