"CRASH"ing with the worm: insights into L1CAM functions and mechanisms.

@article{Chen2010CRASHingWT,
  title={"CRASH"ing with the worm: insights into L1CAM functions and mechanisms.},
  author={Lihsia Chen and Shan Zhou},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2010},
  volume={239 5},
  pages={
          1490-501
        }
}
The L1 family of cell adhesion molecules (L1CAMs) in vertebrates has long been studied for its roles in nervous system development and function. Members of this family have been associated with distinct neurological disorders that include CRASH, autism, 3p syndrome, and schizophrenia. The conservation of L1CAMs in Drosophila and Caenorhabditis elegans allows the opportunity to take advantage of these simple model organisms and their accessible genetic manipulations to dissect L1CAM functions… CONTINUE READING

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