"Blood failure" time to view blood as an organ: how oxygen debt contributes to blood failure and its implications for remote damage control resuscitation.

@article{Bjerkvig2016BloodFT,
  title={"Blood failure" time to view blood as an organ: how oxygen debt contributes to blood failure and its implications for remote damage control resuscitation.},
  author={Christopher Kalhagen Bjerkvig and Geir Strandenes and H{\aa}kon Skogrand Eliassen and Philip C Spinella and Theodor Kaurin Fosse and Andrew P Cap and Kevin R. Ward},
  journal={Transfusion},
  year={2016},
  volume={56 Suppl 2},
  pages={S182-9}
}
Hemorrhagic shock is both a local and systemic disorder. In the context of systemic effects, blood loss may lead to levels of reduced oxygen delivery (DO2 ) sufficient to cause tissue ischemia. Similar to other physiologic debts such as sleep, it is not possible to incur a significant oxygen debt and suffer no consequences for lack of timely repayment. While the linkage between oxygen debt and traditional organ failure (renal, hepatic, lung, and circulation) has been long recognized, we should… CONTINUE READING
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