"Are we there yet?!" Cardiac channelopathy and our journey toward computational medicine.


Half a century ago, Hodgkin and Huxley 1 developed an elegant theoretical model of excitability in nerves, which to date serves as the backbone for mathematical models representing the cardiac action potential. Evolution of such models, from the earliest effort of Noble in 1960,2 to the recent biophysically detailed generation of models,3–5 has been limited… (More)


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