"Are we there yet?": Deciding when one has demonstrated specific genetic causation in complex diseases and quantitative traits.

@article{Page2003AreWT,
  title={"Are we there yet?": Deciding when one has demonstrated specific genetic causation in complex diseases and quantitative traits.},
  author={Grier P. Page and Varghese George and Rodney C. Go and Patricia Zartman Page and David B. Allison},
  journal={American journal of human genetics},
  year={2003},
  volume={73 4},
  pages={711-9}
}
Although mathematical relationships can be proven by deductive logic, biological relationships can only be inferred from empirical observations. This is a distinct disadvantage for those of us who strive to identify the genes involved in complex diseases and quantitative traits. If causation cannot be proven, however, what does constitute sufficient evidence for causation? The philosopher Karl Popper said, "Our belief in a hypothesis can have no stronger basis than our repeated unsuccessful… CONTINUE READING
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