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Each of nine nursing mothers received one single intramuscular injection of 50 mg pethidine (Dolcontral), between the third and eighth days from childbirth. The highest pethidine concentration, 0.526 mumol/l or 0.13 microgrms/ml, was recorded from breast milk, two hours from application. After 24 hours, the concentration had dropped to 0.081 mumol/l or 0.02(More)
BACKGROUND Intracorporeal suturing and knot tying (ICKT) in minimal invasive surgery (MIS) represents a key skill for advanced procedures. Different methods exist for measuring knot quality and performance, but the heterogeneity of these methods makes direct comparisons difficult. The aim of this study is to compare the quality of a laparoscopic knot to one(More)
(NDE) signals is of prime importance, it allows to assess material integrity and quantify detected flaws with reliability. The scope of this Fifth International Workshop will be particularly focused on the cross-fertilization of the fields of NDE and signal processing with participation of international specialists from both fields. Additionally, the(More)
The aim of the experiments was the in vitro-investigation of metabolic reactions of human placentae under different oxygen supply, particularly when oxygenation followed a period of hypoxia. A perfusion system was used with both circuits of a whole placenta being recirculated over 2 hours with blood-containing perfusate. In group A 17 placentae were(More)
The pharmacokinetics of some drugs important for treatment in pregnancy were studied in several groups, women in stage III of pregnancy, women in labour and non-pregnant women as a control group. The half-life of elimination of the drugs is one of the most important parameters in pharmacokinetics. The following drugs were used: noramidopyrine methane(More)
In pregnant women with E-gestosis distribution and elimination of furosemid are significantly different to a non-pregnant control group. Furosemid guarantees a rapid and safe excretion of edemas. The efficiency of furosemid concerning electrolyte excretion is stronger in pregnant women with E-gestosis than in nonpregnant women. Therefore furosemide should(More)
In this paper we represent results concerning pharmacokinetics and bioavailability of iron after the oral application of Vitaferro to women in the second half of pregnancy suffering or not from anaemia in comparison to nonpregnant women. The significance of different parameters used to proof an iron deficiency is discussed. In all pregnant probands the(More)
Pharmacokinetics of the sulphamerazine/trimethoprim-combination Berlocombin-200 was calculated by an one-compartment-model following therapeutic administration in pregnant women and compared with a control group. Distribution parameters are significantly changed, but elimination half-lifes of both the sulphonamide and trimethoprim are not influenced by(More)
The pharmacokinetic parameters were investigated after a single application of 1,0 g of Analgin to women in labour in comparison with a nonpregnant control group. During the late stage of pregnancy the distribution volume is only slightly increasing. For Analgin a fundamental influence on the level of serum concentration could not be shown. The biological(More)