athan Clarke

Learn More
If rehabilitation aims to improve function, the demonstration of its effectiveness requires functional assessment, rather than the standard clinical and laboratory tests beloved of many rheumatologists. Medical interventions are not often evaluated for their contribution to improved function, and this omission must be addressed in the future. The evidence,(More)
Eighty-three patients with primary biliary cirrhosis were investigated to determine the prevalence of rheumatic disorders. 14 had scleroderma, which tended to be mild but in several patients produced severe systemic manifestations. The CRST syndrome (calcinosis, Raynaud's phenomenon, sclerodactyly, telangiectasia) was only identified twice. There was an(More)
The fluid and cellular phases of inflammatory resonse have been measured using a technique employing subcutaneous implantation of polyurethane foam cubes impregnated with heat-killed Mycobacterium tuberculosis. Phenylbutazone, azathioprine, aspirin, cyclophosphamide, and prednisolone suppressed fluid response, whereas sodium aurothiomalate,(More)
A controlled study of 39 consecutively-admitted patients with ankylosing spondylitis was conducted to assess the effects of daily passive stretching of the hip joints during a 3-week in-patient physiotherapy course. Measurements were performed by an independent assessor on admission, at discharge and six months after discharge. Results showed that passive(More)
Methyl prednisolone acetate and hydrocortisone acetate were compared in a trial using the Hypospray to treat tennis elbow. There was little difference between the two preparations as far as side-effects and short-term suppression of symptoms were concerned, both being successful. However, late recurrence was very common in both groups, suggesting that a(More)
The evidence for effectiveness of different approaches is often diluted by the inclusion of heterogeneous groups and, in this case, lack of agreement over what constitutes 'acute' and 'chronic' back pain is a clear confounding factor. Although there are undoubtedly common issues in the approach to these problems, there are also clear differences. Closer(More)
This paper examines the impact of all-star analyst turnover on initial public offering market share and the performance of initial public offerings. We find that investment banks losing all-stars do not experience a uiring the all-star analyst experiences a market share of 1.25 percent. In response to losing a star analyst, investment banks begin to compete(More)
To determine whether anthropometric techniques widely used for assessment of ankylosing spondylitis (AS) would be useful outcome measures in long-term clinical trials, 52 AS patients at the Royal National Hospital for Rheumatic Diseases were studied. All patients had well documented AS with a mean age of 38.1 years, and had been diagnosed for an average of(More)