Zuzana Šišková

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A series of discoveries spanning for the last few years has challenged our view of microglial function, the main form of immune defense in the brain. The surveillance of neuronal circuits executed by each microglial cell overseeing its territory occurs in the form of regular, dynamic interactions. Microglial contacts with individual neuronal compartments,(More)
Structure is a key determinant of function, with the nervous system being no exception. For example, in the nervous system the physiological properties of different synapses may be understood by comparing their structures. However, it is not clear whether specific structural properties of some neurons might play a role in driving their selective removal(More)
We report on a novel transgenic mouse model expressing human full-length Tau with the Tau mutation A152T (hTau(AT)), a risk factor for FTD-spectrum disorders including PSP and CBD Brain neurons reveal pathological Tau conformation, hyperphosphorylation, mis-sorting, aggregation, neuronal degeneration, and progressive loss, most prominently in area CA3 of(More)
The referees appreciate that the analysis is well done, but they are also not convinced that the advance and insight provided is sufficient to consider publication here. In particular referee #2 finds that we gain too limited novel mechanistic insight into how tau promotes neurodegeneration over other models and why the described variant is more toxic that(More)
region specific pre-synaptic and post-synaptic degeneration are early components of neuropathology in prion disease. S tructure is a key determinant of function , with the nervous system being no exception. For example, in the nervous system the physiological properties of different synapses may be understood by comparing their structures. However, it is(More)
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