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Synthesis, structure-activity relationship and biological evaluation of novel nitrogen mustard sophoridinic acid derivatives as potential anticancer agents.
Synthesis, DNA binding, nuclease activity and cytotoxic studies of a wheel‐shaped octanuclear copper(II) complex based on 1,2,4‐triazole
Redox active and inactive binuclear cobalt(II) and zinc(II) complexes with N6O/N3O coordinating ligands: synthesis, biological activities and cytotoxicity
Four complexes, namely [Zn2L1(OAc)2](PF6) (); [Zn2L1(OAc)2](BPh4) (); [Co2L1Cl2](PF6) (); and [Zn2L2(PhCOO)2Cl] () (L1 =…
DNA binding, cleavage, and cytotoxicity of binuclear phenolate nickel(II) complexes
Abstract Three binuclear phenolate complexes, [Ni2(L1)2(OAc)](BPh4)·DMF (1), [Ni2(L2)2(OAc)](BPh4) (2), and [Ni2(L3)2(OAc)](OH)·3H2O (3), where L1 =…
Synthesis, cytotoxicity, topoisomerase I inhibition and molecular docking of novel phosphoramide mustard sophoridinic acid analogues
- Kai Liu, Dongdong Li, Xiumei Zhao, Linlin Dai, Ting Zhang, Zun-Wei Tao
- Chemistry, Biology
- 1 February 2017
Mechanistic studies showed that this class of compounds acted as novel topoisomerase I (Topo I) catalytic inhibitors by preventing the binding of Topo I to DNA and inhibiting the cleavage of DNA, and molecular docking studies revealed that the binding energy for these compounds was comparable to that for classic TopO I inhibitors CPT and HCPT, indicating that the compounds have an interaction with DNA and Topo II.
Polyanthumin, a novel cyclobutane chalcone trimmer from Memecylon polyanthum
- G. Chen, C. Cui, A. Qi, Chang‐Wei Li, Zun-Wei Tao, R. Ren
- ChemistryJournal of Asian natural products research
- 26 January 2015
A novel unusual trimmer chalcone, polyanthumin, together with five known compounds myricetin 3-O-(3″-O-galloyl)-α-l-rhamnopyranoside, which provided the first example of these class flavonoids from the family Melastomataceae and the antitumor activities for 2–4 were reported for the first time in this study.
Comparison of nuclease activities of binuclear metal complexes with N6O coordinating heptadentate ligands: [M2L(OAc)2]+ (M = Ni, Mn, L = 2,6-bis(((2-(dimethylamino)ethyl)(pyridin-2-ylmethyl)amino)…
Four complexes, [Ni2L(OAc)2](PF6) (1), [Ni2L(OAc)2](BPh4) (2), [Mn2L(OAc)2](PF6) (3) and [Mn2L(OAc)2](BPh4) (4) (L =…
Nuclease activity of redox/non-redox active binuclear transition metal mixed-polypyridine complexes: [M2(1,4-tpbd)(diimine)2(H2O)2]4+, M = Zn, Co, Ni, Cd, diimine = phen, bpy, dafo
Seven new transition metal complexes formulated as [M2(1,4-tpbd)(diimine)2(H2O)2]4+ [M = Zn, Co, Ni, Cd; 1,4-tpbd = N,N,N′,N′-tetrakis(2-pyridylmethyl)benzene-1,4-diamine; diimine is a N,N-donor…
Comparison of nuclease activities of redox active and inactive binuclear mixed-polypyridyl complexes: zinc(II)/H2O2 and cadmium(II)/H2O2 systems display efficient nuclease activities
Six binuclear complexes, [Cu2(1,4-tpbd)(bpy)2(ClO4)2](ClO4)2·2DMF (1); [Zn2(1,4-tpbd)(bpy)2(ClO4)2](ClO4)2·4H2O (2); [Ni2(1,4-tpbd)(phen)2(DMF)2](ClO4)4·0.5H2O (3);…
CCDC 1448589: Experimental Crystal Structure Determination