Zuhong Lu

Publications578
h-index42
Citations10,778
Highly Influential Citations308
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MiPred: classification of real and pseudo microRNA precursors using random forest prediction model with combined features
TLDR
The results suggest that the RF method predicts at 98.21% specificity and 95.09% sensitivity, which is nearly 10% greater in total accuracy than the previous study, Triplet-SVM-classifier, which indicated that the improvement was due to both the combined features and the RF algorithm. Expand
The sequence and de novo assembly of the giant panda genome
TLDR
Using next-generation sequencing technology alone, a draft sequence of the giant panda genome is generated and assembled, indicating that its bamboo diet might be more dependent on its gut microbiome than its own genetic composition. Expand
The sequence and de novo assembly of the giant panda genome
TLDR
This corrects the article to show that the Higgs boson genome is a “spatially aggregating ‘spatiotemporal ’ organisation’, rather than a ‘cell-based’ organisation, which is more closely related to the immune system. Expand
Single-Cell Exome Sequencing and Monoclonal Evolution of a JAK2-Negative Myeloproliferative Neoplasm
TLDR
A method for analyzing the cancer genome at a single-cell nucleotide level is described and essential thrombocythemia-related candidate mutations such as SESN2 and NTRK1 are identified, which may be involved in neoplasm progression. Expand
Single-Cell Exome Sequencing Reveals Single-Nucleotide Mutation Characteristics of a Kidney Tumor
TLDR
The pilot study demonstrates that ccRCC may be more genetically complex than previously thought and provides information that can lead to new ways to investigate individual tumors, with the aim of developing more effective cellular targeted therapies. Expand
Analysis of synonymous codon usage in H5N1 virus and other influenza A viruses.
TLDR
It is observed that the codon usage pattern of H5N1 virus is similar with other influenza A viruses, but not influenza B virus, and the synonymouscodon usage in influenza A virus genes is phylogenetically conservative, butNot strain-specific. Expand
Analysis of synonymous codon usage in SARS Coronavirus and other viruses in the Nidovirales
TLDR
It was observed that synonymous codon usage pattern in these virus genes was virus specific and phylogenetically conserved, but it was not host specific, andylogenetic analysis suggested that SARSCoV was diverged far from all three known groups of Coronavirus. Expand
Maternal Plasma miRNAs Expression in Preeclamptic Pregnancies
TLDR
Findings showed that there were differentially expressed maternal plasma miRNAs in patients with preeclampsia, which might be used as notable biomarkers for diagnosis of preeClampsia. Expand
Multiple gene methylation of nonsmall cell lung cancers evaluated with 3‐dimensional microarray
Aberrant DNA methylation of the CpG islands for cancer‐related genes is among the earliest and most frequent alterations in cancer and may be useful for diagnosing cancer or evaluating recurrent… Expand
The Fate of miRNA* Strand through Evolutionary Analysis: Implication for Degradation As Merely Carrier Strand or Potential Regulatory Molecule?
TLDR
The final fate of miRNA* strand, either degraded as merely carrier strand or expressed abundantly as potential functional guide miRNAs with abundant expression, may be destined across evolution. Expand
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