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Members of the Tc1/mariner superfamily of transposons isolated from fish appear to be transpositionally inactive due to the accumulation of mutations. Molecular phylogenetic data were used to… (More)
- Lajos Mátés, Marinee K. L. Chuah, +16 authors Zsuzsanna Izsvák
- Nature Genetics
- 2009
The Sleeping Beauty (SB) transposon is a promising technology platform for gene transfer in vertebrates; however, its efficiency of gene insertion can be a bottleneck in primary cell types. A… (More)
- Stephen R. Yant, Leonard A Meuse, W. Chiu, Zoltán Ivics, Zsuzsanna Izsvák, Mark A. Kay
- Nature Genetics
- 2000
The development of non-viral gene-transfer technologies that can support stable chromosomal integration and persistent gene expression in vivo is desirable. Here we describe the successful use of… (More)
- Ronald H. A. Plasterk, Zsuzsanna Izsvák, Zoltán Ivics
- Trends in genetics : TIG
- 1999
Transgenic technology is currently applied to several animal species of agricultural or medical importance, such as fish, cattle, mosquitos and parasitic worms. However, the repertoire of genetic… (More)
- Zsuzsanna Izsvák, Zoltán Ivics, Ronald H. A. Plasterk
- Journal of molecular biology
- 2000
Sleeping Beauty (SB), a member of the Tc1/mariner superfamily of transposable elements, is the only active DNA-based transposon system of vertebrate origin that is available for experimental… (More)
- Jichang Wang, Gangcai Xie, +13 authors Zsuzsanna Izsvák
- Nature
- 2014
Naive embryonic stem cells hold great promise for research and therapeutics as they have broad and robust developmental potential. While such cells are readily derived from mouse blastocysts it has… (More)
- Csaba Miskey, Zsuzsanna Izsvák, Ronald H. A. Plasterk, Zoltán Ivics
- Nucleic acids research
- 2003
Members of the Tc1/mariner superfamily of transposable elements isolated from vertebrates are transpositionally inactive due to the accumulation of mutations in their transposase genes. A novel open… (More)
- Zsuzsanna Izsvák, Dheeraj Khare, Joachim Behlke, Udo Heinemann, Ronald H. A. Plasterk, Zoltán Ivics
- The Journal of biological chemistry
- 2002
Sleeping Beauty (SB) is the most active Tc1/mariner-like transposon in vertebrate species. Each of the terminal inverted repeats (IRs) of SB contains two transposase-binding sites (DRs). This… (More)
- Hatem Zayed, Zsuzsanna Izsvák, Oliver Walisko, Zoltán Ivics
- Molecular therapy : the journal of the American…
- 2004
The Sleeping Beauty (SB) transposable element is a promising vector for transgenesis in vertebrates and is being developed as a novel, nonviral system for gene therapeutic purposes. A mutagenesis… (More)
- Thomas J Vigdal, Christopher D. Kaufman, Zsuzsanna Izsvák, Daniel F. Voytas, Zoltán Ivics
- Journal of molecular biology
- 2002
Sleeping Beauty (SB) is the most active Tc1/mariner-type transposable element in vertebrates, and is therefore a valuable vector for transposon mutagenesis in vertebrate models and for human gene… (More)