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Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors (PAC1, VPAC) are present in sensory neurons and vascular smooth muscle. PACAP infusion was found to trigger migraine-likeContinue Reading
  • Kata Bölcskei, Zsuzsanna Helyes, Árpád Töhötöm Szabó, Katalin Sandor, János Szolcsányi
  • Medicine
  • Pain
  • 2005 (First Publication: 1 October 2005)
  • Capsaicin-sensitive, TRPV1 (transient receptor potential vanilloid 1) receptor-expressing primary sensory neurons exert local and systemic efferent effects besides the classical afferent function.Continue Reading
  • Bernadett Tuka, Zsuzsanna Helyes, +7 authors János Tajti
  • Medicine
  • Cephalalgia : an international journal of…
  • 2013 (First Publication: 1 October 2013)
  • Background Recent studies on migraineurs and our own animal experiments have revealed that pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) has an important role in activation of theContinue Reading
  • Zsuzsanna Helyes, József Lajos Németh, Márta Thán, Kata Bölcskei, Erika Pintér, János Szolcsányi
  • Biology, Medicine
  • Life sciences
  • 2003 (First Publication: 1 September 2003)
  • Anandamide (AEA) is an endogenous cannabinoid ligand acting predominantly on the cannabinoid 1 (CB(1)) receptor, but it is also an agonist on the capsaicin VR(1)/TRPV(1) receptor. In the presentContinue Reading
  • Éva Sághy, Éva Szőke, +6 authors János Szolcsányi
  • Chemistry, Medicine
  • Pharmacological research
  • 2015 (First Publication: 1 October 2015)
  • Transient Receptor Potential (TRP) cation channels, such as TRP Vanilloid 1 and TRP Ankyrin repeat domain 1 (TRPV1 and TRPA1) are nocisensors playing important role to signal pain. Two "melastatin"Continue Reading
  • Bernadett Tuka, Zsuzsanna Helyes, Adrienn Markovics, Teréz Bagoly, János Tajti
  • Medicine, Chemistry
  • Peptides
  • 2012 (First Publication: 1 February 2012)
  • Pituitary adenylate cyclase activating polypeptide (PACAP) is present in the cranial arteries and trigeminal sensory neurons. We therefore examined the alterations in PACAP-like immunoreactivityContinue Reading
  • Éva Szőke, Rita Börzsei, +4 authors János Szolcsányi
  • Chemistry, Medicine
  • European journal of pharmacology
  • 2010 (First Publication: 1 February 2010)
  • The transient receptor potential vanilloid 1 (TRPV1) is a noxious heat-sensitive, chemonociceptive cation channel which is expressed in primary sensory neurons of polymodal nociceptors. The presentContinue Reading