Zsuzsa Szever

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An increased risk of valproate-induced toxicity has been reported in children, particularly in those younger than 2 years of age. Significant variations in valproate pharmacokinetics and shifts in the metabolic pathways towards CYP2C9-dependent metabolism seem to play some role in the age-related differences in the incidence of adverse events. We present(More)
1 Phenoconversion of CYP2C9 in epilepsy limits the predictive value of 2 CYP2C9 genotype in optimizing valproate therapy 3 4 Katalin Tóth*, Tamás Bűdi*, Ádám Kiss, Manna Temesvári, Edit Háfra, Andrea Nagy, 5 Zsuzsa Szever, Katalin Monostory 6 7 1 Research Centre for Natural Sciences, Hungarian Academy of Sciences 8 Magyar Tudósok 2, H-1117 Budapest, Hungary(More)
OBJECTIVES Valproic acid (VPA)-induced adverse effects, which are sometimes serious in children, can be associated with alterations in VPA metabolism. VPA-evoked toxicity is attributed to both the parent compound and its unsaturated metabolites, primarily formed by the cytochrome P450 (CYP)2C9 enzyme. Thus, patients' CYP2C9-status may account for the(More)
Serological results provided evidence for the clinical diagnosis of chlamydial pneumonia in 8 out of 51 cases. Elevated chlamydia-specific IgM titres (128-2048) and IgG titres (128-2048) were recorded in 5 and 8 infants, respectively. High titres of chlamydial antibodies (512-8192) in the sera of mothers of seropositive children proved genital Chlamydia(More)
Objectives: Valproic acid (VPA)–induced adverse effects, which are sometimes serious in children, can be associated with alterations in VPAmetabolism. VPA-evoked toxicity is attributed to both the parent compound and its unsaturatedmetabolites, primarily formed by the cytochrome P450 (CYP)2C9 enzyme. Thus, patients’ CYP2C9-status may account for the(More)
The authors treated 51 patients suffering from basilar skull fractures between January 1995 and June 1997 following a newly initiated protocol. The effectiveness of recognizing these fractures increased to twice and a half after applying a complex (neurologic, otolaryngologic, ophthalmologic, X-ray and cranial CT) diagnostic examination. CT scans were(More)
Authors summarized the etiology of convulsions in neonatal period and infancy (hypoxia, intracranial hemorrhage, infections of central nervous system, metabolic background, chromosomal abnormalities, brain developmental abnormalities, benign neonatal convulsions, benign neonatal familial convulsions, drug withdrawal, inborn error of metabolism). They(More)
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