beta-Amyloid peptide (A beta), the principal component of senile plaques in Alzheimer's disease, has been found to be neurotoxic. The role of A beta in the deficits of the GABAergic system in patients with Alzheimer's disease is unclear. It has been suggested that the cytotoxic activity of A beta is localized to amino acid residues 25-35 of this peptide,… (More)
The CUBIQ Copernicus project is an attempt at integrating three strands of computing: expert systems, parallel computing, and graphical interaction and visualisation. For core expert system development we use the CUBIQ basic tool-set; parallel computing is supported by the Aurora parallel Prolog system; and the graphical tools have been developed using the… (More)
The effects of ?-amino-n-butyric acid (GABA), (+)bicuculline, isoguvacine and 3-(4-chlorophenyl)-4-aminobutyrate [(+/-)baclofen] on the K-induced release of [(3)H]acetylcholine (ACh) were studied in the superior cervical ganglia of the rat in vitro. GABA and isoguvacine inhibited [(3)H]ACh release and these inhibitions were reversible by (+)bicuculline.… (More)
This paper outlines a project started recently at IQSOFT, aiming to solve system integration problems with a synthesis of knowledge management and logic programming. We focus on analysing the problem domain and point out the feasibility of applying the logic-based knowledge management approach.