Zsolt Kovacs

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One of the main factors driving object-oriented software development in the Web-age is the need for systems to evolve as user requirements change. A crucial factor in the creation of adaptable systems dealing with changing requirements is the suitability of the underlying technology in allowing the evolution of the system. A reflective system utilizes an(More)
Epithelial-to-mesenchymal transition (EMT) is defined as the transformation of an epithelial cell into a spindle cell with the loss of membrane E-cadherin expression and the gain of mesenchymal markers positivity. In the field of colorectal cancer (CRC), first data about EMT was published in 1995 and more than 400 papers had been written up to March 2016.(More)
One of the main factors driving object-oriented software development for information systems is the requirement for systems to be tolerant to change. To address this issue in designing systems, this paper proposes a pattern-based, object-oriented, description-driven system (DDS) architecture as an extension to the standard UML four-layer meta-model. A DDS(More)
As enterprises, data and functions become increasingly complex and distributed the need for information systems to be both customisable and interoperable also increases. Large scale engineering and scientific projects demand flexibility in order to evolve over time and to interact with external systems (both newly designed and legacy in nature) while(More)
Free-form physical models of various high-density plastic foams are extensively used in several application fields. The authors have been developing a new prototyping technology which is the most appropriate for layered fabrication of objects of volumes bigger than 0.6 m3. The new technology is based on (a) an electronically controlled and mechanically set(More)
Retinoprotective effects of pituitary adenylate cyclase activating polypeptide (PACAP) are well-known and have been demonstrated in various pathological conditions, such as diabetic retinopathy, excitotoxic retinal injury, UV light-induced degeneration, and ischemic retinal lesion. The neuronal degeneration observed in the different retinal layers under the(More)
Description-driven systems based on meta-objects are an increasingly popular way to handle complexity in large-scale objectoriented database applications. Such systems facilitate the management of large amounts of data and provide a means to avoid database schema evolution in many settings. Unfortunately, the description-driven approach leads to a loss of(More)