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One of the main factors driving object-oriented software development in the Web-age is the need for systems to evolve as user requirements change. A crucial factor in the creation of adaptable systems dealing with changing requirements is the suitability of the underlying technology in allowing the evolution of the system. A reflective system utilizes an(More)
One of the main factors driving object-oriented software development for information systems is the requirement for systems to be tolerant to change. To address this issue in designing systems, this paper proposes a pattern-based, object-oriented, description-driven system (DDS) architecture as an extension to the standard UML four-layer meta-model. A DDS(More)
As enterprises, data and functions become increasingly complex and distributed the need for information systems to be both customisable and interoperable also increases. Large scale engineering and scientific projects demand flexibility in order to evolve over time and to interact with external systems (both newly designed and legacy in nature) while(More)
Free-form physical models of various high-density plastic foams are extensively used in several application fields. The authors have been developing a new prototyping technology which is the most appropriate for layered fabrication of objects of volumes bigger than 0.6 m 3. The new technology is based on (a) an electronically controlled and mechanically set(More)
Retinoprotective effects of pituitary adenylate cyclase activating polypeptide (PACAP) are well-known and have been demonstrated in various pathological conditions, such as diabetic retinopathy, excitotoxic retinal injury, UV light-induced degeneration, and ischemic retinal lesion. The neuronal degeneration observed in the different retinal layers under the(More)
Software systems are increasingly impinging on new areas in everyday life; competitive market conditions mean that the requirements for such software are subject to frequent change. As a result, there is an increasing need for fast and flexible software development. Meta-objects can be used in multi-layered description-driven systems to represent various(More)
Epithelial-to-mesenchymal transition (EMT) is defined as the transformation of an epithelial cell into a spindle cell with the loss of membrane E-cadherin expression and the gain of mesenchymal markers positivity. In the field of colorectal cancer (CRC), first data about EMT was published in 1995 and more than 400 papers had been written up to March 2016.(More)