Zoumana Koty

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HIV genomic sequence variability has complicated efforts to generate an effective globally relevant vaccine. Regions of the viral genome conserved in sequence and across time may represent the "Achilles' heel" of HIV. In this study, highly conserved T-cell epitopes were selected using immunoinformatics tools combining HLA-A2 supertype binding predictions(More)
In the last decade many advances have been made in understanding how HIV-1 interacts with macrophages (MØ) and dendritic cells (DC). Based on the notion that HIV-2 is a more attenuate model of infection, we proposed to explore the mechanisms of HIV-2 interaction with MØ and DCs. With this aim, we studied the efficiency of cis-infection of MØ and DCs. A(More)
Background HIV treatment in Mali is constrained by limited access to HIV experts. In 2009, GAIA Vaccine Foundation’s “Hope Center Clinic” (HCC), a community health center in Mékin-Sikoro, became one of the first “front-line” clinics to offer HIV treatment in Mali. To assess our HIV prevention strategies and prepare for an eventual HIV vaccine trial, we(More)
Methods Analysis was performed in 2003 on 10,803 HIV-1 sequences, and again in 2009, on an expanded set of 43,822 sequences. These were searched for conserved 910-mer segments with the EpiMatrix suite of immunoinformatic algorithms. From the most highly conserved (>5% isolates) or top 1,000 scoring 9-mers, HLA Class I binding sequences and Class II(More)
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