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  • 分布式序列模式发现算法的研究, Zou Xiang, Wei Zhang, Liu Yang, Qing-Sheng Cai, Zou X +2 others
  • 2005
Algorithm FDMSP (fast distributed mining of sequential patterns) is proposed in order to deal with mining sequential patterns in distributed environment and its properties are analyzed. The algorithm utilizes prefix-projected technique to divide the pattern searching space, utilizes polling site associated with prefix to get a global support, and utilizes(More)
The estrogenic chemical nonylphenol (NP) and the antiandrogenic agent di-n-butyl phthalate (DBP) are regarded as widespread environmental endocrine disruptors (EDCs) which at high doses in some species of laboratory animals, such as mice and rats, have adverse effects on male reproduction and development. Given the ubiquitous coexistence of various classes(More)
Mast cells reside in tissues, where upon activation through the high-affinity-IgE-receptor (FcepsilonRI) they degranulate and orchestrate the allergic reaction. Mast cells survive this activation and can thus be reactivated. In this study we demonstrate that this process depends on the pro-survival gene A1. Activation of mast cells through FcepsilonRI(More)
Fc receptors for IgG are key players in regulating innate and adaptive immunity (1, 2). Fc ␥ RIIb, as the only inhibitory Fc receptor for IgG, plays a unique role in regulating immune responses. It is the only Fc receptor expressed on B cells, where it controls the magnitude and persistence of the response to antigen through eff ects on both mature and(More)
The identification of diagnostic markers and therapeutic candidate genes in common diseases is complicated by the involvement of thousands of genes. We hypothesized that genes co-regulated with a key gene in allergy, IL13, would form a module that could help to identify candidate genes. We identified a T helper 2 (TH2) cell module by small interfering(More)
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Mast cells are critical effector cells mediating immunoglobulin E (IgE)–dependent allergic responses. Binding of an allergen to IgE, already bound to its high-affinity receptor Fc⑀RI on mast cells, leads to aggregation and subsequent activation. This initiates signalling events that typically result in degranulation, changes in gene expression , and the(More)
Microcystin-leucine arginine (MC-LR) is a harmful cyanotoxin produced by cyanobacteria. MC-LR can exert endocrine-disrupting activities in many organisms. We have previously demonstrated that MC-LR exerts both acute and chronic reproductive toxicity in male mice, resulting in a decline in sperm quality and damage to testicular structure. Moreover, we also(More)
Microcystin-leucine arginine (MC-LR) is a potent toxin for Sertoli cells. However, the specific molecular mechanisms of MC-induced cytotoxicity still remain unclear. In this study, we performed a comprehensive analyses of changes of miRNAs and mRNAs in Sertoli cells treated with MC-LR. Through computational approaches, we showed the pivotal roles of(More)
Myofibroblast differentiation of lung resident mesenchymal stem cells (LR-MSC) plays an important role in idiopathic pulmonary fibrosis. By comparing the expression profiles of miRNAs before and after myofibroblast differentiation of LR-MSC, we identified miR-877-3p as a fibrosis-related miRNA. We found that miR-877-3p sequestration inhibited the(More)