Zongyao Chen

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A new class of endomorphin-1 (EM-1) analogues were synthesized by introduction of novel unnatural α-methylene-β-amino acids (Map) at position 3 or/and position 4. Their binding and functional activity, metabolic stability, and antinociceptive activity were determined and compared. Most of these analogues showed high affinities for the μ-opioid receptor and(More)
The whirligig beetle, claimed to be one of the most energy-efficient swimmers in the animal kingdom, has evolved a series of propulsion strategies that may serve as a source of inspiration for the design of propulsion mechanisms for energy-efficient surface swimming. In this paper, we introduce a robot platform that was developed to test an energy-efficient(More)
Whirligig beetle, claimed in the literature to be one of the highest measured for a thrust-generating apparatus within the animal kingdom, has evolved a series of propulsion strategies that may serve as a source of inspiration for designing highly efficient propulsive systems. First, a robotic platform was developed to test an energy-efficient propulsion(More)
Human hemokinin-1 (hHK-1) is a substance P-like tachykinin peptide preferentially expressed in non-neuronal tissues. It is involved in multiple physiological functions such as inflammation, hematopoietic cells development and vasodilatation via the interaction with tachykinin receptor neurokinin-1 (NK1). To further understand the intracellular signal(More)
We present herein for the first time the synthesis and preliminary biological evaluation of various modified chromanes via a rosin-derived tertiary amine-thiourea-catalyzed highly enantioselective Friedel-Crafts alkylation reaction.
Strain/stress evolution during welding is essential to understand material's mechanical behavior and the formation of weld defects such as distortion, cracks and residual stresses. In-situ measurement of strain has been very challenging due to the impact from high temperature and intense arc light. In this work, a newly-developed integrated optical system(More)
The bio-inspired materials and bio-inspired robotics laboratory at the University of Tennessee developed a swimming robot with a rigid body and flexible propellers inspired from the whirligig beetle. We improved the propulsion efficiency by identifying the optimal structure for the propellers and beating patterns to minimize the energy consumption for this(More)
Aquatic animal movement results from a complex balance between muscular actuation, swimmer's inertia, damping, and stiffness; as well as, the effects from the fluid environment. Most aquatic animals utilize undulatory propulsion methods during swimming. Propulsion mode transition involves a variation of these parameters, and to better investigate the(More)
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