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Special AT-rich sequence-binding protein-1 participates in the maintenance of breast cancer stem cells through regulation of the Notch signaling pathway and expression of Snail1 and Twist1
- Zhengkui Sun, Chao Zhang, +4 authors Hui-Juan Xie
- Biology, Medicine
- Molecular medicine reports
- 13 January 2015
Results indicated that expression of SATB1 may increase the size of the BCSC population via the activation of the Notch signaling pathway and by increasing expression levels of Snail1 and Twist1. Expand
Norcantharidin Suppresses Colon Cancer Cell Epithelial-Mesenchymal Transition by Inhibiting the αvβ6-ERK-Ets1 Signaling Pathway
Norcantharidin could induce morphological changes in colon cancer cells, causing a transition from a spindle-shaped morphology to a typical round or oval shape, which was indicative of a mesenchymal-epithelial transition (MET) process. Expand
Natural Orifice Total Transtracheal Endoscopic Thyroidectomy Surgery: First Reported Experiment.
- E. Liu, Abdul Qadir Khan, J. Niu, Zongquan Xu, Cheng Peng
- Journal of laparoendoscopic & advanced surgical…
- 2 July 2015
The transtracheal endoscopic thyroidectomy technique is feasible and has the potential to be an alternative method for other types of thyroid surgeries. Expand
Hypoxia-inducible factor-1alpha suppressed hepatocellular carcinoma cell apoptosis through influencing on Omi/HtrA2 expression and its releasing from the mitochondrion.
The results demonstrated that HIF-1alpha suppressed hepatocellular carcinoma cell apoptosis through inhibiting Omi/HtrA2 expression and upregulating Bcl-2 expression to impede Omi / HtrA 2 releasing from the mitochondrion. Expand
Screening of significant biomarkers related with prognosis of liver cancer by lncRNA‐associated ceRNAs analysis
A nomogram model consisting of pathologic_T and a risk score assessment model could be regarded as an independent factor for predicting prognosis of liver cancer. Expand
Omi/HtrA2 pro-apoptotic marker differs in various hepatocellular carcinoma cell lines owing to ped/pea-15 expression level.
The results showed that Omi/HtrA2 overexpression promotes hepatocellular carcinoma cell apoptosis and the ped/pea-15 expression level causes this difference of the Omi-Htr a2 pro-apoptotic marker in the various hepato cellular carcinomas cell lines. Expand
A SOX9‐AS1/miR‐5590‐3p/SOX9 positive feedback loop drives tumor growth and metastasis in hepatocellular carcinoma through the Wnt/β‐catenin pathway
It is demonstrated that a SOX9‐AS1/miR‐5590‐3p/SOX9 positive feedback loop drives tumor growth and metastasis in HCC through the Wnt/β‐catenin pathway, suggesting SOX7‐AS2 as a novel potential prognostic and treatment target for HCC. Expand
Role of hypoxia-inducible-1α in hepatocellular carcinoma cells using a Tet-on inducible system to regulate its expression in vitro.
A Tet-on system is used to stably and effectively regulate and acquire significant results that HIF-1α facilitates cell proliferation and cell cycle and suppresses cell apoptosis through inducing the expression of survivin and Bcl-2. Expand
Integrin αvβ6 plays a bi-directional regulation role between colon cancer cells and cancer-associated fibroblasts
It is found that colorectal cancer (CRC) cells expressing integrin αvβ6 clearly could induce morphological changes in inactive fibroblasts and increased the expression of activated fibroblast markers such as α-smooth muscle actin (α-SMA) and Fibroblast-activating protein (FAP), which may serve as a therapeutic target for the future CRC treatment. Expand
The expression and clinical significance of Omi/Htra2 in hepatocellular carcinoma.
Both univariate and multivariate analysis using the Cox regression model indicated that Omi/HtrA2 expression was a significant factor for prognosis as well as a significant inverse correlation between the expression of Omi,/HtraA2 and HIF-1α in hepatocellular carcinoma. Expand