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Two highly related transcription factors, activating transcription factors a and 2 (ATFa and ATF2) are able to activate expression in CHO cells of a reporter gene driven by the human transforming growth factor beta 2 gene promoter. This action is dependent on the intact motif CGTCA which is found as part of the cAMP responsive element in a number of(More)
Transient transfection of pLB2CAT constructs bearing short synthetic oligonucleotides derived either from the tyrosine hydroxylase (TH) promoter or other sources was used to examine functional cAMP regulatory element (CRE) activity in a variety of cell lines. The region containing only the putative TH CRE was found to be as or more effective in conferring(More)
Estrogen exhibits mitogenic activity in early ovarian carcinogenesis and plays an important role in ovarian tumorigenesis. Due to the increased expression of ERα and decreased expression of the ERβ, the ratio of ERα and ERβ is markedly increased in ovarian cancer. We have recently reported that PES1 regulates the balance of ERα and ERβ at the(More)
Gastric cancer is one of the leading causes of cancer death worldwide. However, precise molecular mechanisms underlining its development are far from clear. We recently reported that PES1 promoted development of breast cancer and ovarian cancer as an oncogene. In this study, we reported that ablation of endogenous PES1 resulted in significant suppression of(More)
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