Zoltan Balazs

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Microglia, the resident macrophage-like cells in the brain, regulate innate immune responses in the CNS to protect neurons. However, excessive activation of microglia contributes to neurodegenerative diseases. Corticosteroids are potent modulators of inflammation and mediate their effects by binding to mineralocorticoid receptors (MR) and glucocorticoid(More)
11Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is essential for the local activation of glucocorticoid receptors (GR). Unlike unliganded cytoplasmic GR, 11beta-HSD1 is an endoplasmic reticulum (ER)-membrane protein with lumenal orientation. Cortisone might gain direct access to 11beta-HSD1 by free diffusion across membranes, indirectly via(More)
BACKGROUND The role of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in the regulation of energy metabolism and immune system by locally reactivating glucocorticoids has been extensively studied. Experiments determining initial rates of enzyme activity revealed that 11beta-HSD1 can catalyze both the reductase and the dehydrogenase reaction in(More)
2008. SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. 2013. In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation. Identification of disease specific pathways using in vivo SILAC proteomics in dystrophin deficient mdx(More)
1. Spatz, J. P. et al. Ordered deposition of inorganic clusters from micellar block copolymer films. Molecular imprinting of biomineralized CdS nanostructures: Crystallographic control using self-assembled DNA-membrane templates. Coupled synthesis and self-assembly of nanoparticles to give structures with controlled organization.selective organization of(More)
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