Zoltán Ujfalusi

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Hypertrophic cardiomyopathy (HCM) is the most frequently occurring inherited cardiovascular disease. It is caused by mutations in genes encoding the force-generating machinery of the cardiac sarcomere, including human β-cardiac myosin. We present a detailed characterization of the most debated HCM-causing mutation in human β-cardiac myosin, R403Q. Despite(More)
At the latest count the myosin family includes 35 distinct groups, all of which have the conserved myosin motor domain attached to a neck or lever arm, followed by a highly variable tail or cargo binding region. The motor domain has an ATPase activity that is activated by the presence of actin. One feature of the myosin ATPase cycle is that it involves an(More)
The ends of coiled-coil tropomyosin molecules are joined together by nine to ten residue-long head-to-tail "overlapping domains". These short four-chained interconnections ensure formation of continuous tropomyosin cables that wrap around actin filaments. Molecular Dynamics simulations indicate that the curvature and bending flexibility at the overlap is(More)
Modeling the complete actin.myosin ATPase cycle has always been limited by the lack of experimental data concerning key steps of the cycle, because these steps can only be defined at very low ionic strength. Here, using human β-cardiac myosin-S1, we combine published data from transient and steady-state kinetics to model a minimal eight-state ATPase cycle.(More)
Doctoral School: I n t e r d i s c i p l i n a r y M e d i c a l S c i e n c e s D o c t o r a l S c h o o l D 9 3 Head of the Doctoral School: P r o f . D r . B a l á z s S ü m e g i P r o g r a m : B 1 3 0 ; I n v e s t i g a t i n g f u n c t i o n a l p r o t e i n d y n a m i c s u s i n g b i o p h y s i c a l m e t h o d s H e a d o f t h e P r o g r(More)
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA. School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK. Department of Molecular, Cellular and Developmental Biology, BioFrontiers Institute, University of Colorado, Boulder, CO 80309, USA. Department of Pediatrics (Cardiology), Stanford University School(More)
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA. School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK. Department of Molecular, Cellular and Developmental Biology, BioFrontiers Institute, University of Colorado, Boulder, CO 80309, USA. Department of Pediatrics (Cardiology), Stanford University School(More)
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