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Properties, solution state behavior, and crystal structures of chelates of DOTMA.
It is reported that the tetramethylated DOTA derivative, DOTMA, possess several properties that, from an imaging agent development point of view, are more advantageous than those of the parent DOTA. Expand
Lanthanide(III) complexes with a reinforced cyclam ligand show unprecedented kinetic inertness.
The structure of the complexes in the solid state is retained in solution, as demonstrated by the analysis of the Yb(3+)-induced paramagnetic shifts. Expand
Stable Mn(2+), Cu(2+) and Ln(3+) complexes with cyclen-based ligands functionalized with picolinate pendant arms.
The results of the equilibrium, dissociation kinetics, DFT and X-ray crystallographic studies performed on the complexes of metal ions of biomedical importance formed with octadentate ligands based on a cyclen platform incorporating two picolinate pendant arms are presented. Expand
Effect of the Nature of Donor Atoms on the Thermodynamic, Kinetic and Relaxation Properties of Mn(II) Complexes Formed With Some Trisubstituted 12-Membered Macrocyclic Ligands
Equilibrium, kinetic parameters, and relaxivity of the Mn(II) complexes formed with 12-membered macrocyclic ligands were studied, finding that the phosphonate pedant should not be considered as a suitable building block for further ligand design while the tertiary amide moiety will likely have some implications in this respect in the future. Expand
Comparison of the equilibrium, kinetic and water exchange properties of some metal ion-DOTA and DOTA-bis(amide) complexes.
Data indicate that even though the Ln(DO2A2MnBu)+ complexes have lower thermodynamic stabilities, their kinetic inertness should be sufficient for in vivo use. Expand
Approaching the Kinetic Inertness of Macrocyclic Gadolinium(III)-Based MRI Contrast Agents with Highly Rigid Open-Chain Derivatives.
The kinetic inertness of this novel chelate is superior by 2-3 orders of magnitude compared to non-macrocyclic MRI contrast agents approved for clinical use. Expand
Remarkable differences and similarities between the isomeric Mn(II)-cis- and trans-1,2-diaminocyclohexane-N,N,N′,N′-tetraacetate complexes
Equilibrium, kinetic (solvent exchange and dissociation of the complex) and relaxometric studies (1H and 17O NMR) have been performed with the [M(II)(c-cdta)]2− complexes (c-cdta =Expand
Physico-chemical properties of MnII complexes formed with cis- and trans-DO2A: thermodynamic, electrochemical and kinetic studies.
Mn(cis-DO2A) displays some very interesting features (thermodynamic and redox stability as well as kinetic inertness) which makes this complex a promising platform for the development of more efficient MnII complexes as alternatives to Gd-based MRI agents. Expand
Mn(II)-based MRI contrast agent candidate for vascular imaging.
A macrocyclic chelate, [Mn(PC2A-BP], is reported, which possesses high thermodynamic stability and kinetic inertness as well as remarkable relaxivity in the presence of human serum albumin allowing a significant MRI signal intensity increase in the vasculature even at low dose. Expand
Taking the next step toward inert Mn2+ complexes of open-chain ligands: the case of the rigid PhDTA ligand
In line with our research to find inert Mn(II) complexes as contrast agents for magnetic resonance imaging, we have studied the aromatic-ring rigidified EDTA-analogueExpand