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Twenty-five AIDS patients were treated with HE2000, a synthetic adrenal hormone. The drug was well tolerated and safe and reduced both the incidence of tuberculosis coinfection by 42.2% (P < 0.05) and the cumulative incidence of opportunistic infections (P < 0.05). These results warrant further clinical investigation of HE2000.
BACKGROUND Oropharyngeal candidiasis (OPC) is the most common opportunistic infection among persons infected with human immunodeficiency virus (HIV). Once-daily miconazole 50 mg buccal tablet (MBT) is a novel delivery system using an extended-spectrum azole with potent in vitro activity against many Candida species, including some that may be resistant to… (More)
Methods 138 subjects with mean CD4 of 336 cells/ul and mean HIV-RNA of 4.9 log were enrolled in this GCP, ICH-compliant study. Subjects were randomized to receive either VGV-1 monotherapy (bovine-derived thymus nuclear protein in alum, presumable immune modulator) or control via 16 biweekly i.m. injections and followed to 240 days. Effects of… (More)