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Myocardial infarction (MI) is associated with oxidative stress, which may cause cardiac autonomic impairment. We tested the hypothesis that acute MI disrupts cardiac cholinergic signaling by impairing nitric oxide (NO)-cGMP modulation of acetylcholine (ACh) release and whether the restoration of this pathway following cardiac neuronal NO synthase (nNOS)(More)
We assessed patient-reported outcomes in 34 women who had had their breasts reconstructed with a deep inferior epigastric perforator (DIEP) flap, and compared them with those of 24 patients who were waiting for breast reconstruction. Both groups completed the Short Form 36 (SF-36) questionnaire. The DIEP flap group also assessed their preoperative(More)
BACKGROUND Day-case surgery, theatre direct admissions and elective surgery have revolutionised the surgical patient's pathway, and have minimised the length of their hospital stay. However, with large numbers of medical students placed mostly at teaching hospitals, this has also significantly reduced students' exposure to clinical signs in surgery. This(More)
Quantum state engineering of ultracold matter and precise control of optical fields have together allowed accurate measurement of light-matter interactions for applications in precision tests of fundamental physics. State-of-the-art lasers maintain optical phase coherence over one second. Optical frequency combs distribute this optical phase coherence(More)
BACKGROUND Designing RCTs in surgery requires consideration of existing evidence, stakeholders' views and emerging interventions, to ensure that research questions are relevant to patients, surgeons and the health service. When there is uncertainty about RCT design, feasibility work is recommended. This study aimed to assess how feasibility work could(More)
INTRODUCTION There is variation in margin policy for breast conserving therapy (BCT) in the UK and Ireland. In response to the Society of Surgical Oncology and American Society for Radiation Oncology (SSO-ASTRO) margin consensus ('no ink on tumour' for invasive and 2 mm for ductal carcinoma in situ [DCIS]) and the Association of Breast Surgery (ABS)(More)
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