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— Spiking neural networks (SNNs) have been shown capable of replicating the spike patterns observed in biological neuronal networks, and of learning via biologically-plausible mechanisms, such as synaptic time-dependent plasticity (STDP). As result, they are commonly used to model cultured neural network, and memristor-based neuromorphic computer chips that(More)
BACKGROUND Midbrain dopaminergic neurons code a computational quantity, reward prediction error (RPE), which has been causally related to learning. Recently, this insight has been leveraged to link phenomenological and biological levels of understanding in psychiatric disorders, such as schizophrenia. However, results have been mixed, possibly due to small(More)
Early identification efforts for psychosis have thus far yielded many more individuals "at risk" than actually develop psychotic illness. Here, we test whether measures of reinforcement learning (RL), known to be impaired in chronic schizophrenia, are related to the severity of clinical risk symptoms. Because of the reliance of RL on dopamine-rich(More)
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