Zina M. Ibrahim

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This paper extends a mereotopological theory of spatiotemporal reasoning to vague ”egg-yolk” regions. In this extension, the egg and its yolk are allowed to move and change over time. We present a classification of motion classes for vague regions as well as composition tables for reasoning about moving vague regions. We also discuss the formation of(More)
Alzheimer's disease (AD), like other dementias, is characterized by progressive neuronal loss and neuroinflammation in the brain. The peripheral leukocyte response occurring alongside these brain changes has not been extensively studied, but might inform therapeutic approaches and provide relevant disease biomarkers. Using microarrays, we assessed blood(More)
This paper demonstrates the use of qualitative probabilistic networks (QPNs) to aid Dynamic Bayesian Networks (DBNs) in the process of learning the structure of gene regulatory networks from microarray gene expression data. We present a study which shows that QPNs define monotonic relations that are capable of identifying regulatory interactions in a manner(More)
OBJECTIVES Electronic healthcare records (EHRs) are a rich source of information, with huge potential for secondary research use. The aim of this study was to develop an application to identify instances of Adverse Drug Events (ADEs) from free text psychiatric EHRs. METHODS We used the GATE Natural Language Processing (NLP) software to mine instances of(More)
This paper motivates the use of Qualitative Probabilistic Networks (QPNs) in conjunction with or in lieu of Bayesian Networks (BNs) for reconstructing gene regulatory networks from microarray expression data. QPNs are qualitative abstractions of Bayesian Networks that replace the conditional probability tables associated with BNs by qualitative influences,(More)
Clinical outcome measures are well-established quantitative assessments of medical treatment that are crucial for understanding the effectiveness of prescribed drugs. However, recent studies suggest that timely and long-term clinical outcome measures are not usually found in the patient records. The study attributes the lack of quantitative follow-up to the(More)
Cellular processes are known to be modular and are realized by groups of proteins implicated in common biological functions. Such groups of proteins are called functional modules, and many community detection methods have been devised for their discovery from protein interaction networks (PINs) data. In current agglomerative clustering approaches, vertices(More)