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Propionic acid is an important short-chain fatty acid with many applications, but its large-scale bioproduction was hindered by the low productivity. An adapted acid-tolerant Propionibacterium acidipropionici CGMCC 1.2230 strain was selected to produce propionic acid with a relatively high productivity (0.29 g/(Lh)) in the free-cell fermentation. Further(More)
Groundwater composition and coupled redox cycles can affect the long-term stability of U(IV) products from bioremediation. The effects of Mn(II), a redox active cation present at uranium-contaminated sites, on UO2 dissolution in both oxic and anoxic systems were investigated using batch and continuous-flow reactors. Under anoxic conditions Mn(II) inhibited(More)
The stability of UO2 is critical to the success of reductive bioremediation of uranium. When reducing conditions are no longer maintained, Mn redox cycling may catalytically mediate the oxidation of UO2 and remobilization of uranium. Ligand-stabilized soluble Mn(III) was recently recognized as an important redox-active intermediate in Mn biogeochemical(More)
The inclusion of multidentate adsorption reactions has improved the ability of surface complexation models (SCM) to predict adsorption to mineral surfaces, but variation in the mass action expression for these reactions has caused persistent ambiguity and occasional mishandling. The principal differences are the exponent (α) for the activity of available(More)
Pulmonary arterial hypertension (PAH) is an incurable cardiovascular disease characterized by high blood pressure in the arteries leading from the heart to the lungs. Over two million people in the USA are diagnosed with PAH annually and the typical survival rate is only 3 years after diagnosis. Current treatments are insufficient because of limited(More)
Lead(IV) oxide (PbO(2)) is a corrosion product on lead pipes used for drinking water distribution, and its dissolution can control lead release to drinking water. This study evaluated the adsorption of Pb(II) to PbO(2) and its impact on the dissolution rate of PbO(2). The dissolution rate of PbO(2) was determined as a function of pH in the absence and(More)
Pulmonary antibiotic delivery is increasingly recommended as maintenance therapy for cystic fibrosis (CF) patients with chronic Pseudomonas aeruginosa infection. However, the abnormally thick and sticky mucus present in the respiratory tract of CF patients impairs efficient mucus penetration and limits the range of antibiotics for inhalation treatment. To(More)
Biocompatible, biodegradable polymers are commonly used as excipients to improve the drug delivery properties of aerosol formulations, in which acetalated dextran (Ac-Dex) exhibits promising potential as a polymer in various therapeutic applications. Despite this promise, there is no comprehensive study on the use of Ac-Dex as an excipient for dry powder(More)
Nanocomposite microparticle (nCmP) systems exhibit promising potential in the application of therapeutics for pulmonary drug delivery. This work aimed at identifying the optimal spray-drying condition(s) to prepare nCmP with specific drug delivery properties including small aerodynamic diameter, effective nanoparticle (NP) redispersion upon nCmP exposure to(More)
The mobility of hexavalent uranium in soil and groundwater is strongly governed by adsorption to mineral surfaces. As strong naturally occurring adsorbents, manganese oxides may significantly influence the fate and transport of uranium. Models for U(VI) adsorption over a broad range of chemical conditions can improve predictive capabilities for uranium(More)