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Making a definitive preoperative diagnosis of solitary pulmonary nodules (SPNs) found by CT has been a clinical challenge. We previously demonstrated that microRNAs (miRNAs) could be used as biomarkers for lung cancer diagnosis. Here we investigate whether plasma microRNAs are useful in identifying lung cancer among individuals with CT-detected SPNs. By(More)
The use of arsenic trioxide (As2O3, ATO) combined with all-trans retinoic acid (ATRA) has recently been reported to induce remission in patients with acute promyelocytic leukemia (APL). However, its efficiency remains inconclusive mainly due to the small number of the available cases. In this study, therefore, we present a clinical study using a combination(More)
We sequenced the RNA genome of hepatitis E virus (HEV) recovered from an acute hepatitis patient living in Changchun, China. The HEV-CCC220 isolate thus obtained was 7,193 nt in length and contained ORF1 (5121 nt, 1706 aa), ORF2 (2025 nt, 674 aa), and ORF3 (345 nt, 114 aa) plus uncompleted 5' and 3' untranslated regions. When compared with full-genome(More)
Adefovir dipivoxil (AD) is a bis(pivaloyloxymethyl) prodrug of adefovir with chemical stability problem. It undergoes two degradation pathways including hydrolysis and dimerization during storage. Pharmaceutical cocrystallization exhibits a promising approach to enhance aqueous solubility as well as physicochemical stability. In this study we attempted to(More)
Chronic myeloid leukemia (CML) is a clonal disorder characterized by excessive accumulation of myeloid cells in the peripheral blood. In the present study, to investigate the role of Hiwi in leukemogenesis, lentivirus-mediated Hiwi overexpression was performed in a CML cell line, K562 cells. Our data revealed that Hiwi protein expression was undetectable in(More)
Circulating tumor cells (CTCs) have emerged as a potential biomarker in the diagnosis, prognosis, treatment, and surveillance of lung cancer. However, CTC detection is not only costly, but its sensitivity is also low, thus limiting its usage and the collection of robust data regarding the significance of CTCs in lung cancer. We aimed to seek clinical(More)
The present study aimed to study the mechanisms by which low dose arsenic trioxide (As(2)O(3)) reduces multidrug resistance. The potential influence of As(2)O(3) on cytotoxicity was examined by methyl thiazolyl tetrazolium (MTT) assay and the intracellular mean fluorescence intensity (MFI) of Adriamycin (ADM) was examined by flow cytometry. The gene(More)
OBJECTIVE To explore the interaction of Mycoplasma pneumoniae (M. pneumoniae) capsular polysaccharide (CPS) with dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) and its influence on the secretions of IL-10 and IL-12. METHODS M. pneumoniae CPS and lipid-associated membrane proteins (LAMPs) were extracted and(More)
OBJECTIVE To investigate the effect of magnetic nanoparticles (MNPs) of Fe(3)O(4) combined with cyclosporin A (CsA) on acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in murine models. METHODS BALB/c mice preconditioned with total-body irradiation generated aGVHD and then were followed with(More)
Although some studies have reported relationships between cytogenetic subgroups, molecular markers and age in acute myeloid leukemia (AML), conclusions based on data from a Chinese population are lacking. In the present study, we evaluated 640 patients with de novo AML. The patients were divided into 8 age groups, i.e. 0-9, 10-19, 20-29, 30-39, 40-49,(More)