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Serum metabolites are associated with all-cause mortality in chronic kidney disease.
Chronic kidney disease (CKD) involves significant metabolic abnormalities and has a high mortality rate. Because the levels of serum metabolites in patients with CKD might provide insight intoExpand
Biological Variability of Estimated GFR and Albuminuria in CKD.
RATIONALE & OBJECTIVE Determining whether a change in estimated glomerular filtration rate (eGFR) or albuminuria is clinically significant requires knowledge of short-term within-person variabilityExpand
Serum metabolomic profile of incident diabetes
Aims/hypothesisMetabolomic profiling offers the potential to reveal metabolic pathways relevant to the pathophysiology of diabetes and improve diabetes risk prediction.MethodsWe prospectivelyExpand
Serum untargeted metabolomic profile of the Dietary Approaches to Stop Hypertension (DASH) dietary pattern.
Background The Dietary Approaches to Stop Hypertension (DASH) dietary pattern is recommended for cardiovascular disease risk reduction. Assessment of dietary intake has been limited to subjectiveExpand
Variability of Two Metabolomic Platforms in CKD.
BACKGROUND AND OBJECTIVES Nontargeted metabolomics can measure thousands of low-molecular-weight biochemicals, but important gaps limit its utility for biomarker discovery in CKD. These include theExpand
Serum metabolites associated with dietary protein intake: results from the Modification of Diet in Renal Disease (MDRD) randomized clinical trial.
BACKGROUND Accurate assessment of dietary intake is essential, but self-report of dietary intake is prone to measurement error and bias. Discovering metabolic consequences of diets with lowerExpand
High normal blood pressure in early pregnancy also contribute to early onset preeclampsia and severe preeclampsia
ABSTRACT Objective: This study was to evaluate effects of high normal blood pressure (HNBP) in early pregnancy on total preeclampsia, early preeclampsia, and severe preeclampsia. Methods: WeExpand
The Dietary Fructose:Vitamin C Intake Ratio Is Associated with Hyperuricemia in African-American Adults.
Background A high fructose intake has been shown to be associated with increased serum urate concentration, whereas ascorbate (vitamin C) may lower serum urate by competing with urate for renalExpand
Gestational Weight Gain and Pregnancy Complications in a High-Risk, Racially and Ethnically Diverse Population.
BACKGROUND Evidence used to guide the current Institute of Medicine (IOM) gestational weight gain (GWG) recommendations is largely derived from studies of European descent, and as such the guidelinesExpand
Subtyping CKD Patients by Consensus Clustering: The Chronic Renal Insufficiency Cohort (CRIC) Study.
BACKGROUND CKD is a heterogeneous condition with multiple underlying causes, risk factors, and outcomes. Subtyping CKD with multidimensional patient data holds the key to precision medicine.Expand