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Prader-Willi region non-protein coding RNA 1 suppressed gastric cancer growth as a competing endogenous RNA of miR-425-5p.
TLDR
It is suggested that PWRN1 functioned as a ceRNA targetting miR-425-5p and suppressed GC development via p53 signaling pathway and prevented proliferation and metastasis in GC cells. Expand
hsa_circ_0092306 Targeting miR-197-3p Promotes Gastric Cancer Development by Regulating PRKCB in MKN-45 Cells
  • Zihao Chen, H. Ju, +7 authors Y. Li
  • Medicine, Chemistry
  • Molecular therapy. Nucleic acids
  • 16 August 2019
Gastric cancer (GC) is one of the most common cancers worldwide and is thus a global cancer burden. Here, we focused on a novel circular RNA hsa_circ_0092306 and explored the potential molecularExpand
The role of surgery in stage I to III small cell lung cancer: A systematic review and meta-analysis
TLDR
Surgery-based multi-modality treatment appears to be associated with a favorable survival advantage in stage I and selected stage II to III SCLC and Lobectomy is likely to provide superior OS when compared to sublobar resection. Expand
Effect of PLK1 inhibition on cisplatin‐resistant gastric cancer cells
TLDR
PLK 1 inhibition, including si‐PLK1 and BI2536 treatment, could restore the chemosensitivity of drug‐resistant SGC‐7901/DDP cells and enhance the efficacy of DDP, revealing the potential value of PLK1 inhibition in GC chemotherapy. Expand
Achievements and futures of immune checkpoint inhibitors in non-small cell lung cancer
TLDR
The novel therapies of checkpoint inhibitors in NSCLC treatment and some other potential immunotherapy to provide a conspectus for novel immunotherapy in NSclC and perspective for the future in anti-cancer treatment are summarized. Expand
Identification of miR-200c and miR141-Mediated lncRNA-mRNA Crosstalks in Muscle-Invasive Bladder Cancer Subtypes
TLDR
The results show that the luminal subtype of muscle-invasive bladder cancer (MIBC) is primarily characterized by upregulation of metabolism-related pathways while the basal subtype is predominantly characterized byUpregulation of epithelial-mesenchymal transition, metastasis, and immune system process- related pathways. Expand
Manganese‐12 acetate suppresses the migration, invasion, and epithelial–mesenchymal transition by inhibiting Wnt/β‐catenin and PI3K/AKT signaling pathways in breast cancer cells
TLDR
This research aims to reveal the molecular mechanisms of breast cancer progression and develop new therapeutic targets for diagnosis and treatment of women with breast cancer. Expand
A co-expression network for differentially expressed genes in bladder cancer and a risk score model for predicting survival
TLDR
The gene co-expression network-based study could provide additional insight into the tumorigenesis and progression of BLCA, and the proposed risk score model may aid physicians in the assessment of the prognosis of patients with B LCA. Expand
Mn12Ac inhibits the migration, invasion and epithelial-mesenchymal transition of lung cancer cells by downregulating the Wnt/β-catenin and PI3K/AKT signaling pathways
TLDR
The results suggested that Mn12Ac is able to inhibit cell migration, invasion and EMT in lung cancer cells by regulating the Wnt/β-catenin and PI3K/AKT signaling pathways. Expand
Influential factors and prognostic analysis of blood vessel invasion in advanced gastric cancer.
TLDR
It is found that BVI was not only closely related to lymph node metastasis, but also an independent predictor of prognosis of advanced gastric cancer. Expand
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