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Identification of absorbed constituents and metabolites in rat plasma after oral administration of Shen-Song-Yang-Xin using ultra-performance liquid chromatography combined with quadrupole
TLDR
The results indicated that the absorbed constituents and metabolites mainly came from benzocyclooctadiene lignans, tanshinones, isoquinoline alkaloids and triterpenic acids, while phase I reactions were the main metabolic pathways of these ingredients in SSYX. Expand
Quantification and semiquantification of multiple representative components for the holistic quality control of Allii Macrostemonis Bulbus by ultra high performance liquid chromatography with
TLDR
This work illustrated that the proposed approach could improve the quality of Allii Macrostemonis Bulbus, and it also provided a feasible method for quality evaluation of other traditional Chinese medicines. Expand
Metabolic profiling of corylin in vivo and in vitro
TLDR
Corylin was subjected to massive first‐pass metabolism in liver and intestine, while CYP1A1, 1B1, 2C19 and UGT1A 1 were the main contributors and the proposed metabolic pathway of corylin involed CYP and U GT isoforms were summarized, which could help to understand the metabolic fate of c Corylin in vivo. Expand
In vivo metabolic profiles of Bu-Zhong-Yi-Qi-Tang, a famous traditional Chinese medicine prescription, in rats by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight
TLDR
A four-step integrated strategy based on ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UHPLC-Q-TOF/MS) was established to systematically screen the in vivo xenobiotics of BZYQT and provides an important basis for further studying the pharmacokinetics of BzYQt to exploreIts in vivo disposal features and discover its in vivo bioactive components. Expand
Metabolites profile of Gualou Xiebai Baijiu decoction (a classical traditional Chinese medicine prescription) in rats by ultra-performance liquid chromatography coupled with quadrupole time-of-flight
  • P. Lin, Zifei Qin, +6 authors X. Yao
  • Chemistry, Medicine
  • Journal of chromatography. B, Analytical…
  • 15 May 2018
TLDR
A reliable "representative structure based homologous xenobiotics identification" (RSBHXI) strategy based on ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF-MS) were applied to investigate the chemical components in GLXB extracts and indicated dehydration, hydrolysis, hydroxylation, methylation, glucuronidation and sulfation were the main metabolic reactions. Expand
Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing
  • L. Wang, X. Hong, +6 authors X. Yao
  • Chemistry, Medicine
  • Xenobiotica; the fate of foreign compounds in…
  • 1 April 2018
TLDR
Icaritin was subjected to significant glucuronidation, wherein UGT1A3, 1A9 and 2B7 were main contributing enzymes and Relative activity factors and activity correlation analysis were performed to identify main UGT isoforms. Expand
Efflux excretion of bisdemethoxycurcumin‐O‐glucuronide in UGT1A1‐overexpressing HeLa cells: Identification of breast cancer resistance protein (BCRP) and multidrug resistance‐associated proteins 1
TLDR
Chemical inhibition and gene silencing results both indicated that generated BDMC-O-glucoside were excreted primarily by the BCRP and MRP1 transporters. Expand
Chemical inhibition and stable knock-down of efflux transporters leads to reduced glucuronidation of wushanicaritin in UGT1A1-overexpressing HeLa cells: the role of breast cancer resistance protein
TLDR
Chemical inhibition and gene silencing results suggested that BCRP, MRP1, MRp3 and MRP4 were significant contributors to excretion of wushanicaritin glucuronides. Expand
Non-volatile pungent compounds isolated from Zingiber officinale and their mechanisms of action.
TLDR
The integrated strategy developed by integrating UPLC-Q/TOF-MS, network pharmacology, and molecular simulation, was proposed and applied for rapidly screening bioactive candidates from ginger, providing a good possibility of screening new lead compounds from natural sources. Expand
Identification, bioactivity evaluation and pharmacokinetics of multiple components in rat serum after oral administration of Xian-Ling-Gu-Bao capsule by ultra performance liquid chromatography
TLDR
Compared to single-compound dosing, significantly enhanced responses were obtained when several analytes were administered simultaneously, indicating possible drug-drug interactions among the complex ingredients of TCMP. Expand
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