Zia Shariat-Madar

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BACKGROUND Prolylcarboxypeptidase (Prcp) gene, along with altered PRCP and kallikrein levels, have been implicated in inflammation pathogenesis. PRCP regulates angiotensin 1-7 (Ang 1-7) - and bradykinin (BK) - stimulated nitric oxide production in endothelial cells. The mechanism through which kallikrein expression is altered during infection is not fully(More)
We argue that the potential benefits of developing high-fidelity models of biological communication systems has enormous potential in terms of enhancing the understanding of biological systems and that such understanding is a major step towards detection and treatment of disease. By focusing on lysosomal enzyme response to stimuli, we demonstrate that the(More)
Recently, we serendipitously discovered that mice with the deficiency of the enzyme prolylcarboxypeptidase (PRCP) have elevated alpha-melanocyte-stimulating hormone (alpha-MSH) levels which lead to decreased food intake and weight loss. This suggests that PRCP is an endogenous inactivator of alpha-MSH and an appetite stimulant. Since a modest weight loss(More)
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