Zia Shariat-Madar

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We argue that the potential benefits of developing high-fidelity models of biological communication systems has enormous potential in terms of enhancing the understanding of biological systems and that such understanding is a major step towards detection and treatment of disease. By focusing on lysosomal enzyme response to stimuli, we demonstrate that the(More)
A novel redox-responsive amphiphilic polymer was synthesized with bioreductive trimethyl-locked quinone propionic acid for a potential triggered drug delivery application. The aim of this study was to synthesize and characterize the redox-responsive amphiphilic block copolymer micelles containing pendant bioreductive quinone propionic acid (QPA) switches.(More)
BACKGROUND Prolylcarboxypeptidase (Prcp) gene, along with altered PRCP and kallikrein levels, have been implicated in inflammation pathogenesis. PRCP regulates angiotensin 1-7 (Ang 1-7) - and bradykinin (BK) - stimulated nitric oxide production in endothelial cells. The mechanism through which kallikrein expression is altered during infection is not fully(More)
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