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BACKGROUND Partial or total flap necrosis after flap transplantation is sometimes encountered in reconstructive surgery, often as a result of a period of hypoxia that exceeds the tolerance of the flap tissue. The purpose of this study was to determine whether Tanshinone IIA (TSA) pretreatment can protect flap tissue against hypoxic injury and improve its(More)
The process of angiogenesis is essential for tumor development and metastasis. Vascular endothelial growth factor (VEGF), which is overexpressed in most human cancers, has been demonstrated to be a major modulator of angiogenesis. Thus, inhibition of VEGF signaling has the potential for tumor anti-angiogenic therapy. Signal transducer and activator of(More)
Partial or total flap necrosis after flap transplantation is sometimes clinically encountered in reconstructive surgery, often as a result of a period of hypoxia that exceeds the tolerance of the flap tissue. In this study, we determine whether tanshinone IIA (TSA) pretreatment can protect flap tissue against hypoxic injury and improve its viability.(More)
OBJECTIVE To investigate the effect of delayed skin grafting combined traction in severe joint cicatricial contracture. METHODS At the first stage, the joint cicatricial contracture was released completely with protection of vessels, nerves and tendons. The wound was covered with allogenetic skin or biomaterials. After skin traction for 7-14 days, the(More)
Two new steroidal saponins, (25R)-3β-hydroxy-5α-spirost-9-en-12-one 3-O-β-D-galactopyranoside (hostasaponin A, 1), and (25R)-2α,3β-dihydroxy-5α-spirost-12-one 3-O-β-D-galactopyranoside (hostasaponin B, 2), together with a new natural product, 2α,3β-dihydroxy-5α-pregn-16-en-20-one (3), were isolated from the rhizomes of Hosta plantaginea, a perennial herb(More)
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