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Mitochondrial calcium uniporter inhibition provides cardioprotection in pressure overload-induced heart failure through autophagy enhancement.
- Zi-qing Yu, Ruizhen Chen, +7 authors J. Ge
- International journal of cardiology
- 15 November 2018
BACKGROUND HF incurs high disease burden, and the effectiveness of known HF treatments is unsatisfactory. Therefore, seeking novel therapeutic target of HF is important. The present study aimed to… Expand
Rapid predictors for the occurrence of reduced left ventricular ejection fraction between LAD and non-LAD related ST-elevation myocardial infarction
BackgroundsReduced left ventricular ejection fraction (LVEF) after acute myocardial infarction (AMI), which implies the occurrence of cardiac dysfunction, impacts cardiac prognosis, even after… Expand
Identification of biomarkers in macrophages of atherosclerosis by microarray analysis
BackgroundAtherosclerotic cardiovascular disease (ASCVD) refers to a series of diseases caused by atherosclerosis (AS). It is one of the most important causes of death worldwide. According to the… Expand
Comparison between cardiac resynchronization therapy with and without defibrillator on long-term mortality: A propensity score matched analysis.
BACKGROUND Cardiac resynchronization therapy (CRT)-defibrillator (CRT-D) has been more widely implanted than CRT-pacemaker (CRT-P) in patients of heart failure with reduced ejection fraction and… Expand
Protective effects of cardiac resynchronization therapy in a canine model with experimental heart failure by improving mitochondrial function: a mitochondrial proteomics study
Purpose Cardiac resynchronization therapy (CRT) is well acknowledged as an effective treatment for dyssynchronous heart failure. However, the molecular mechanism is unclear to date. Mitochondrial… Expand
Circulating metabolite profiles to predict response to cardiac resynchronization therapy
Background Heart failure is associated with ventricular dyssynchrony and energetic inefficiency, which can be alleviated by cardiac resynchronization therapy (CRT) with approximately one-third of… Expand
Research progress on HIV infection in chronic obstructive pulmonary disease
- Zi-qing Yu
- 5 August 2019
Acquired human immunodeficiency virus (HIV) infection is a risk factor for chronic obstructive pulmonary disease (COPD). With the introduction of new research methods and the development of a large… Expand
Mechanisms of cardiac resynchronization therapy ameliorating failing heart function via regulating mitochondrial calcium uniporter expression
Objective To investigate the mechanisms of cardiac resynchronization therapy (CRT) in improving failing heart function via modulating mitochondrial calcium homeostasis. Methods Beagles Heart… Expand