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The association between pro-inflammatory cytokines and depression has been reported by many studies. However, the mechanisms by which inflammation affects mood are only partially understood. In this study, we detected depression-like behavior in a rat animal model which was induced inflammation in the spleen and brain by chronic mild stress (CMS). Wistar(More)
Despite the potential adverse effects of maternal sleep deprivation (MSD) on physiological and behavioral aspects of offspring, the mechanisms remain poorly understood. The present study was intended to investigate the roles of microglia on neurodevelopment and cognition in young offspring rats with prenatal sleep deprivation. Pregnant Wistar rats received(More)
Although sleep complaints are very common among pregnant women, the potential adverse effects of sleep disturbance on the offspring are not well studied. Growing evidence suggests that maternal stress can induce an inflammatory environment on the fetal development. But people are not sure about the consequences of prenatal stress such as the inflammatory(More)
AIM OF STUDY To determine the effect of jujuboside A (JuA) in modulating the gamma-aminobutyric acid (GABA(A)) receptor subunits gene expression of hippocampal neurons at different terms in vitro. MATERIALS AND METHODS Hippocampal neurons of rat were cultured in vitro, treated with JuA or diazepam (DZP). Then GABA(A) receptor mRNAs were evaluated by(More)
For the electroencephalogram (EEG), topographic differences in the long-range temporal correlations would imply that these signals might be affected by specific mechanisms related to the generation of a given neuronal process. So the properties of the generators of various EEG oscillations might be investigated by their spatial differences of the long-range(More)
BACKGROUND Abundant researches indicate that neuroinflammation has important roles in the pathophysiology of depression. Our previous study found that the NLRP3 inflammasome mediated stress-induced depression-like behavior in mice via regulating neuroinflammation. However, it still remains unclear that how the NLRP3 inflammasome influences related(More)
AbstractAim:To investigate the effect of jujuboside A (JuA) on modulating gene expression in the hippocampus.Methods:The spontaneous activity of mice was monitored, and the differential display polymerase chain reaction was adapted to screen differentially-expressed genes modulated by JuA in the mouse hippocampus.Results:JuA significantly decreased the(More)
OBJECTIVE To provide basis for the exploring of the mechanism and improvement of the efficacy of DNA vaccines, through the analysis of CpG motifs in endoflagellar gene (flaB2) and expression vector (VR1012) of the Leptospiral DNA vaccine. METHODS Directed by Kreig's immunostimulatory nucleic acid molecules, we undertook the computer-assisted analysis of(More)
Although accumulating evidence suggests that activated microglia are associated with deficits in neurogenesis and contribute to the physiopathology of major depressive disorder, the role of microglia in treating depression remains poorly understood. Our previous study showed that salvianolic acid (SalB) has the regulation of neuroinflammatory responses and(More)