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hrombospondin (TSP)-1 has been reported to modulate T cell behavior both positively and negatively. We found that these opposing responses arise from interactions of TSP1 with two different T cell receptors. The integrin ␣ 4 ␤ 1 recognizes an LDVP sequence in the NH 2-terminal domain of TSP1 and was required for stimulation of T cell adhesion, chemotaxis,(More)
Dietary modifications have been shown to contribute to the physical and mental diseases. Oxidative modifications of protein can be easily found in protein-rich food such as meat and milk products. Previous studies mainly focus on the consequences of lipid oxidation products intake in vivo, but the effects of protein oxidation products consumption have been(More)
As software systems are becoming increasingly complex, they need to dynamically and continually adapt their behavior to changing conditions in the long-term running. There will be large numbers of adaptations in these systems when evolving and the adaptations may be unknowable until system operation. To specify these adaptations, this paper proposes the(More)
BACKGROUND This study aims to investigate the role of OX40 ligand (OX40L) in ocular inflammation via abrogation of retinal pigment epithelium (RPE)-mediated immunosuppression using an in vitro expression approach. OX40L cDNA was polymerase chain reaction-amplified and cloned into an eYFP fusion vector. Cultured retinal pigment epithelial cells (ARPE-19)(More)
Due to the dynamic, heterogeneous and interorganizational nature, different web services and different ports or operations in the same service, even the same services at different times may have their different security requirements because of their different security domains and different business backgrounds. How to design a flexible, fine-grained and(More)